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Nov 15, 2012 · Patients with lung cancer with activating mutations in the EGF receptor (EGFR) kinase, who are treated long-term with tyrosine kinase inhibitors (TKI), often develop secondary mutations in EGFR associated with resistance. Mice engineered to develop lung adenocarcinomas driven by the human EGFR T790M resistance mutation are similarly resistant to the EGFR TKI erlotinib. By tumor …
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Record details - The Biosafety Clearing-House (BCH)
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However, the precise molecular composition of lipids in tumors remains generally poorly characterized. The aim of the present study was to analyze the global lipid profiles of breast cancer, integrate the results to protein expression, and validate the findings by functional experiments Record details - The Biosafety Clearing-House (BCH) The 98140 maize has been genetically modified (GM) to express the GAT4621 and ZM-HRA proteins. The GAT4621 protein is a glyphosate acetyltransferase (GAT), encoded by an optimized form of the gat gene from Bacillus licheniformis. Record details - The Biosafety Clearing-House (BCH) The term Recipient organism refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas Parental organisms refers to those that were involved in cross breeding or cell fusion.
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